Calcium Propionate
Also known as: Propionic acid calcium salt
Preservative · E282
US-EU Regulatory Divergence
This additive has different regulatory status in the US and EU — what's permitted in one region may be restricted or banned in the other.
Regulatory Status
United States (FDA)
GRASFDA GRAS status. The most common bread preservative.
European Union (EFSA)
ApprovedApproved in EU. No ADI established (considered safe).
Safety Profile
Widely considered safe. Propionic acid is a normal human metabolite. The behavioral study is a single small trial that has not been replicated.
Health Concerns
- • Small Australian study linked it to irritability and restlessness in children
- • Natural metabolite — the body produces and metabolizes propionic acid routinely
- • Generally well-tolerated
Commonly Found In
Sources: FDA Substances Added to Food, EFSA opinions, EU Regulation 1333/2008, IARC monographs
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.