Polysorbate 80

Also known as: Tween 80

Emulsifier · E433

Regulatory Status

United States (FDA)

Approved

FDA-approved for food use and as vaccine excipient.

European Union (EFSA)

Approved

Approved in EU. Under re-evaluation by EFSA.

Safety Profile

Approved in both regions. Emerging research on gut health effects. The vaccine-related concerns have no scientific basis at the trace amounts used.

Health Concerns

  • • Animal studies suggest it may promote intestinal inflammation
  • • May alter gut microbiome composition
  • • Used as a talking point in anti-vaccine rhetoric (unwarranted)

Commonly Found In

Ice creamSaucesVaccinesCosmeticsPharmaceuticals

Sources: FDA Substances Added to Food, EFSA opinions, EU Regulation 1333/2008, IARC monographs

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.