Saccharin
Also known as: Sweet'N Low, E954
Artificial sweetener · E954
Regulatory Status
United States (FDA)
ApprovedFDA-approved. Was briefly labeled with cancer warning (1977-2000) based on rat studies; warning removed after human studies showed no risk.
European Union (EFSA)
ApprovedApproved in EU with ADI of 5 mg/kg body weight/day.
Safety Profile
The original artificial sweetener scare story. Rat studies in the 1970s caused a cancer warning label that lasted 23 years before being removed. Human studies found no cancer risk.
Health Concerns
- • Historical cancer scare (rat bladder tumors — mechanism not relevant to humans)
- • Bitter aftertaste at high concentrations
Commonly Found In
Sources: FDA Substances Added to Food, EFSA opinions, EU Regulation 1333/2008, IARC monographs
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.