Sucralose

Also known as: Splenda, E955, 1,6-DICHLORO-1,6-DIDEOXY-BETA-D-FRUCTOFURANOSYL 4-CHLORO-4-DEOXY-ALPHA-D-GALACTOPYRANOSIDE, 4,1',6'-TRICHLORO-4,1',6'-TRIDEOXYGALACTOSUCROSE, 1',4,6'-TRICHLORO-1',4,6'-TRIDEOXYGALACTOSUCROSE, 4,1',6'-TRICHLOROGALACTOSUCROSE, TRICHLOROGALACTOSUCROSE, 1',4,6'-TRICHLOROGALACTOSUCROSE

Artificial sweetener · E955

Regulatory Status

United States (FDA)

Approved

FDA-approved since 1998. 600x sweeter than sugar. No caloric value.

European Union (EFSA)

Approved

Approved in EU. EFSA ADI: 15 mg/kg body weight/day.

Safety Profile

Both FDA and EFSA consider it safe at current ADI. Emerging research on gut microbiome effects is under review but hasn't changed regulatory status.

Health Concerns

• 2023 WHO report classified as "possibly not safe" for weight loss
• Some studies suggest it may alter gut microbiome
• Heating sucralose may produce harmful chlorinated compounds

Commonly Found In

Diet beveragesSugar-free foodsBaked goodsTabletop sweetener

Sources: FDA Substances Added to Food, EFSA opinions, EU Regulation 1333/2008, IARC monographs

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.