Acalabrutinib: Uses, Side Effects, and Drug Interactions

Brand names: CALQUENCE

# Acalabrutinib (CALQUENCE): What You Need to Know Acalabrutinib is a prescription medicine used to treat certain types of blood cancers, including chronic lymphocytic leukemia and mantle cell lymphoma. These are cancers that affect white blood cells. The drug works by blocking a protein that helps cancer cells grow and survive. By stopping this protein, acalabrutinib helps slow down or stop the cancer from spreading in your body. If you take acalabrutinib, it's important to know about some safety concerns. This medicine can interact with other drugs you might be taking, especially certain medications that affect how your body processes acalabrutinib. You should avoid taking strong CYP3A inhibitors (a type of medication) with acalabrutinib, and you may need a lower dose if you take moderate CYP3A inhibitors. Always tell your doctor about all medications, vitamins, and supplements you're taking. Also, make sure to take acalabrutinib exactly as prescribed and report any side effects to your doctor right away.

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Most Reported Side Effects (FAERS)

  • DEATH1,938 reports
  • FATIGUE611 reports
  • HEADACHE579 reports
  • PRODUCT DOSE OMISSION ISSUE383 reports
  • DIARRHOEA372 reports
  • FALL312 reports
  • MALIGNANT NEOPLASM PROGRESSION300 reports
  • CONTUSION297 reports
  • DYSPNOEA293 reports
  • PNEUMONIA282 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.