Acetaminophen: Uses, Side Effects, and Drug Interactions

Brand names: Pain Reliever Extra Strength

# Acetaminophen Overview Acetaminophen is a common medicine used to reduce fever and relieve pain like headaches, muscle aches, and minor arthritis pain. You can find it in many over-the-counter products at drugstores, and it works by helping your body lower its temperature and reduce the feeling of pain. Many people use acetaminophen safely every day when they follow the directions on the bottle. However, it's important to use acetaminophen carefully to stay safe. Never take more than the recommended dose, and be careful because acetaminophen is found in many different products—if you take multiple medicines, you might accidentally get too much of it, which can damage your liver. Don't use acetaminophen if you're allergic to it, and check with your doctor before using it if you have liver problems or drink alcohol regularly. Keep the medicine in a safe place away from children, and if you're pregnant or breastfeeding, talk to your doctor before taking it.

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE50,705 reports
  • PAIN48,247 reports
  • FATIGUE43,980 reports
  • OVERDOSE40,185 reports
  • NAUSEA40,135 reports
  • DRUG DEPENDENCE39,120 reports
  • OFF LABEL USE37,537 reports
  • HEADACHE37,158 reports
  • DEATH35,608 reports
  • DIARRHOEA30,920 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Recent Recalls (5)

Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.

Supplement Interactions (1)

These dietary supplements may interact with Acetaminophen. Always consult your healthcare provider.

  • severe
    kava

    Kava has been associated with severe liver damage. Combining with hepatotoxic drugs increases risk.

    Avoid kava if taking medications that affect the liver.

Check interactions with Acetaminophen:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.