Acetaminophen: Uses, Side Effects, and Drug Interactions
Brand names: Pain Reliever Extra Strength
# Acetaminophen Overview Acetaminophen is a common medicine used to reduce fever and relieve pain like headaches, muscle aches, and minor arthritis pain. You can find it in many over-the-counter products at drugstores, and it works by helping your body lower its temperature and reduce the feeling of pain. Many people use acetaminophen safely every day when they follow the directions on the bottle. However, it's important to use acetaminophen carefully to stay safe. Never take more than the recommended dose, and be careful because acetaminophen is found in many different products—if you take multiple medicines, you might accidentally get too much of it, which can damage your liver. Don't use acetaminophen if you're allergic to it, and check with your doctor before using it if you have liver problems or drink alcohol regularly. Keep the medicine in a safe place away from children, and if you're pregnant or breastfeeding, talk to your doctor before taking it.
Taking Acetaminophen with other medications?
Check Acetaminophen against any other medication — the form below is already pre-filled.
Check Now ↓Most Reported Side Effects (FAERS)
- DRUG INEFFECTIVE50,705 reports
- PAIN48,247 reports
- FATIGUE43,980 reports
- OVERDOSE40,185 reports
- NAUSEA40,135 reports
- DRUG DEPENDENCE39,120 reports
- OFF LABEL USE37,537 reports
- HEADACHE37,158 reports
- DEATH35,608 reports
- DIARRHOEA30,920 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (5)
- Class II
SpecGx, LLC · December 16, 2025
Oxycodone and Acetaminophen CII Tablets USP, 7.5 mg/325 mg, 100 tablets, Rx only, SpecGx LLC, Webster Groves, MO 63119, NDC 0406-0522-01. Case label: SpecGx LLC, NDC 0406052201, Exp. 2027/03, Lot: 05Failed Tablet/Capsule Specification: There is a potential for the imprint to be missing on tablets.
- Class II
SpecGx, LLC · December 16, 2025
Oxycodone and Acetaminophen CII Tablets USP, 10mg/325 mg, 100 tablets, Rx only, SpecGx LLC, Webster Groves, MO 63119, NDC 0406-0523-01.Failed Tablet/Capsule Specification: There is a potential for the imprint to be missing on tablets.
- Class II
Aurobindo Pharma USA Inc · May 22, 2025
Acetaminophen Tablets, 325 mg, 100-count bottles, Distributed by: Amazon.com Services LLC, 410 Terry Avenue N., Seattle, WA 98109, NDC 72288-405-10cGMP deviations: Due to confirmed consumer complaints received with the observation of tablet discoloration (brown surface on tablets).
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Supplement Interactions (1)
These dietary supplements may interact with Acetaminophen. Always consult your healthcare provider.
- severekava
Kava has been associated with severe liver damage. Combining with hepatotoxic drugs increases risk.
Avoid kava if taking medications that affect the liver.
Check interactions with Acetaminophen:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.