Acetaminophen 500mg / Diphenhydramine Hcl 25mg: Uses, Side Effects, and Drug Interactions

Brand names: Extra strength Acetaminophen PM

# Overview of Acetaminophen 500mg / Diphenhydramine HCl 25mg This medicine combines two active ingredients to help relieve pain and help you sleep better. The acetaminophen reduces pain and fever, while the diphenhydramine is an antihistamine that causes drowsiness. Together, they work to ease discomfort from headaches, body aches, and minor pain while helping you rest. This medication is designed for adults and children 12 years and older who need pain relief and sleep support at the same time. Before taking this medicine, it's important to know some safety rules. Don't use this product if you're allergic to any ingredients or if you're taking other medications without asking your doctor first. Since this medicine causes drowsiness, never drive or operate machinery after taking it. Don't use it for more than a few days without talking to a doctor, and always follow the dosage instructions on the package carefully. Keep this medication away from children, and if someone takes too much, call poison control right away. If you're pregnant, breastfeeding, or have any health conditions, talk to your doctor before using this product.

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Most Reported Side Effects (FAERS)

  • FATIGUE20 reports
  • HEADACHE13 reports
  • PAIN12 reports
  • DRUG INEFFECTIVE9 reports
  • INSOMNIA9 reports
  • WEIGHT DECREASED9 reports
  • ARTHRALGIA8 reports
  • FALL8 reports
  • AMNESIA7 reports
  • ANXIETY7 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with Acetaminophen 500mg / Diphenhydramine Hcl 25mg:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.