Acetaminophen And Diphenhydramine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: ACETAMINOPHEN PM

# Acetaminophen and Diphenhydramine Hydrochloride Overview This medicine combines two active ingredients to help you feel better when you're sick. Acetaminophen reduces fever and relieves pain, while diphenhydramine hydrochloride is an antihistamine that helps dry up congestion and can make you drowsy so you can rest. Together, they're commonly used to treat cold and flu symptoms like aches, fever, stuffy nose, and sneezing. This medication can help you get some relief when you're uncomfortable and need to sleep. Before taking this medicine, it's important to know some safety rules. Never use it if you're allergic to either ingredient, and be careful not to take other medicines that contain these same ingredients, or you could take too much. This medicine can make you very sleepy, so don't drive or operate machinery after taking it. Keep it away from young children and pets, store it at room temperature in a dry place, and always follow the dosage directions on the package. If you're pregnant, nursing a baby, or have certain health conditions, talk to your doctor or pharmacist before using this medication.

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Most Reported Side Effects (FAERS)

  • FATIGUE449 reports
  • NAUSEA355 reports
  • DIARRHOEA284 reports
  • DIZZINESS259 reports
  • DRUG INEFFECTIVE252 reports
  • INSOMNIA244 reports
  • PAIN244 reports
  • HEADACHE237 reports
  • ASTHENIA207 reports
  • OFF LABEL USE205 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.