Acetaminophen And Phenylephrine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: Sinus Pressure and Pain PE

# Acetaminophen and Phenylephrine Hydrochloride Overview This medicine combines two active ingredients to help you feel better when you have a cold or flu. Acetaminophen reduces fever and helps ease pain and body aches, while phenylephrine hydrochloride helps clear your stuffy nose so you can breathe easier. Together, they work to relieve multiple cold symptoms at the same time. This type of medicine is commonly found in over-the-counter cold and flu products that you can buy without a prescription. Before taking this medicine, it's important to follow the dosage instructions carefully and never take more than recommended. Don't use this medicine if you're allergic to either ingredient, and be careful if you have heart problems, high blood pressure, or thyroid issues. If you're pregnant, breastfeeding, or taking other medications, talk to a doctor or pharmacist first. Stop using the medicine and call a doctor if you experience chest pain, severe headache, or trouble breathing. Always keep this medicine out of reach of children and store it at room temperature in a dry place.

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Most Reported Side Effects (FAERS)

  • FOETAL EXPOSURE DURING PREGNANCY4 reports
  • INCORRECT DOSE ADMINISTERED4 reports
  • AUTISM SPECTRUM DISORDER2 reports
  • BLOOD PRESSURE INCREASED2 reports
  • HEADACHE2 reports
  • INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION2 reports
  • OFF LABEL USE2 reports
  • PRODUCT USE IN UNAPPROVED INDICATION2 reports
  • BLOOD URINE PRESENT1 reports
  • CARDIAC ARREST1 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.