Acetaminophen-aspirin-caffeine: Uses, Side Effects, and Drug Interactions

Brand names: Extra Strength Headache, Caseys 4good

# Acetaminophen-Aspirin-Caffeine Overview This medicine is a combination of three ingredients that work together to relieve pain and reduce fever. Acetaminophen and aspirin are pain relievers and fever reducers, while caffeine helps your body absorb these medicines better and may make them work faster. People use this medication for headaches, muscle aches, backaches, minor arthritis pain, toothaches, menstrual cramps, and the common cold. It's available over-the-counter, meaning you can buy it without a prescription at most pharmacies and stores. It's important to use this medicine safely. Don't take it if you're allergic to any of the ingredients, and be careful not to take more than the recommended dose on the package. Don't use this medicine for more than 10 days unless your doctor says it's okay. If you're pregnant, breastfeeding, or have certain health conditions like liver disease, stomach ulcers, or asthma, talk to your doctor before using it. Keep this medicine away from children and store it at room temperature. If you have questions about whether this medicine is right for you or how to take it, ask a pharmacist or doctor.

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE86 reports
  • EXPIRED PRODUCT ADMINISTERED79 reports
  • OFF LABEL USE49 reports
  • NAUSEA29 reports
  • UNDERDOSE23 reports
  • DRUG INEFFECTIVE FOR UNAPPROVED INDICATION22 reports
  • INCORRECT DOSE ADMINISTERED21 reports
  • DIZZINESS20 reports
  • ABDOMINAL PAIN UPPER18 reports
  • HEADACHE18 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.