Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, And Phenylephrine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: Cold Multi-Symptom Daytime and Nighttime

# Consumer Overview: Multi-Symptom Cold & Flu Medicine This medicine contains four active ingredients that work together to help you feel better when you have a cold or flu. Acetaminophen reduces fever and pain, chlorpheniramine maleate dries up a runny nose and sneezing, dextromethorphan stops your cough, and phenylephrine hydrochloride clears nasal congestion so you can breathe easier. It's designed to treat multiple cold symptoms at the same time, which is why it's often called a "multi-symptom" cold medicine. You can buy this medicine without a prescription at drugstores and pharmacies. Before you take this medicine, there are some important safety rules to follow. Never use it if you're allergic to any of the ingredients, and don't give it to children under a certain age—check the package for age limits. Be careful not to take other medicines that also contain acetaminophen, since taking too much can hurt your liver. Don't use this medicine if you have certain health conditions or take certain other medicines, so talk to a doctor or pharmacist first if you're unsure. Stop taking it and call a doctor if you experience serious side effects like chest pain, trouble breathing, or severe dizziness. Keep the medicine away from children and pets, store it at room temperature, and always follow the dosage instructions on the package.

Taking Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, And Phenylephrine Hydrochloride with other medications?

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Most Reported Side Effects (FAERS)

  • OFF LABEL USE180 reports
  • VOMITING141 reports
  • DRUG ADMINISTERED TO PATIENT OF INAPPROPRIATE AGE132 reports
  • WRONG TECHNIQUE IN PRODUCT USAGE PROCESS125 reports
  • INCORRECT DOSE ADMINISTERED123 reports
  • PRODUCT USE ISSUE107 reports
  • DRUG INEFFECTIVE106 reports
  • PRODUCT ADMINISTERED TO PATIENT OF INAPPROPRIATE AGE94 reports
  • ACCIDENTAL EXPOSURE TO PRODUCT BY CHILD88 reports
  • PRODUCT USE IN UNAPPROVED INDICATION76 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, And Phenylephrine Hydrochloride:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.