Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl: Uses, Side Effects, and Drug Interactions

Brand names: RESFRIOL D

# Overview of This Cold and Allergy Medicine This medicine is a combination of three active ingredients that work together to help relieve cold and allergy symptoms. Acetaminophen reduces fever and eases aches and pains. Chlorpheniramine maleate is an antihistamine that dries up a runny nose and stops sneezing and itching caused by allergies. Phenylephrine HCl is a decongestant that helps clear a stuffy nose so you can breathe better. People use this medicine when they have a cold, the flu, or allergies and need relief from multiple symptoms at the same time. Before taking this medicine, it's important to follow the dosage instructions carefully, as taking too much could be harmful. Don't use this medicine if you're allergic to any of its ingredients, and be careful if you're pregnant, breastfeeding, or giving it to children—you should talk to a doctor first in these situations. This medicine can make you feel drowsy, so don't drive or operate machinery after taking it. Also, avoid using other over-the-counter medicines that contain acetaminophen at the same time, since that could cause you to take too much. Keep this medicine out of reach of children and store it at room temperature in a dry place.

Taking Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl with other medications?

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE4,247 reports
  • FATIGUE3,245 reports
  • HEADACHE3,059 reports
  • NAUSEA2,894 reports
  • DYSPNOEA2,872 reports
  • DIARRHOEA2,323 reports
  • PAIN2,313 reports
  • DIZZINESS2,167 reports
  • COUGH1,834 reports
  • OFF LABEL USE1,740 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.