Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: Nighttime SEVERE

# Overview of This Cold & Flu Medicine This medicine is used to treat multiple cold and flu symptoms at the same time. It contains four active ingredients that work together: acetaminophen reduces fever and aches, dextromethorphan stops coughing, doxylamine helps you sleep, and phenylephrine clears your stuffy nose. People take this medicine when they have a combination of these symptoms and want relief from all of them in one dose. It's available without a prescription at drugstores, but you should still follow the directions carefully. Before taking this medicine, there are important safety rules to follow. Never take it if you're allergic to any ingredient or if you're using certain other medicines. Don't give it to children unless directed by a doctor, and keep it away from young kids. You should talk to a doctor or pharmacist before using it if you're pregnant, breastfeeding, or have certain health conditions. Always follow the dosage instructions on the package—taking too much can be dangerous, especially since it contains acetaminophen. If your symptoms don't improve after a few days or get worse, stop taking it and call your doctor.

Taking Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine Hydrochloride with other medications?

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Most Reported Side Effects (FAERS)

  • CHOKING12 reports
  • FOREIGN BODY IN THROAT8 reports
  • VOMITING4 reports
  • DIZZINESS3 reports
  • DYSPNOEA3 reports
  • OROPHARYNGEAL PAIN3 reports
  • PRODUCT USE COMPLAINT3 reports
  • FOREIGN BODY IN RESPIRATORY TRACT2 reports
  • NAUSEA2 reports
  • RETCHING2 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine Hydrochloride:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.