Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, And Phenylephrine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: Cold and Flu

# Consumer Overview of Combination Cold and Flu Medicine This medicine contains four active ingredients that work together to help you feel better when you have a cold or flu. Acetaminophen reduces fever and pain, dextromethorphan stops your cough, guaifenesin helps loosen mucus so you can cough it up more easily, and phenylephrine hydrochloride helps clear a stuffy nose. Together, these ingredients tackle multiple cold symptoms at once, making it easier to rest and recover while you're sick. When using this medicine, it's important to follow the dosage instructions carefully and never take more than recommended, since acetaminophen can be harmful in large amounts. Don't use this medicine if you're allergic to any of its ingredients, and talk to a doctor before using it if you're pregnant, breastfeeding, or taking other medicines. Keep this medication away from children, and store it at room temperature in a safe place. If you accidentally take too much, call poison control right away. If your symptoms don't improve after a few days or get worse, stop taking the medicine and contact your doctor.

Taking Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, And Phenylephrine Hydrochloride with other medications?

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Most Reported Side Effects (FAERS)

  • COVID-19129 reports
  • DISEASE RECURRENCE107 reports
  • NAUSEA71 reports
  • NASOPHARYNGITIS65 reports
  • DIZZINESS58 reports
  • FATIGUE56 reports
  • DIARRHOEA54 reports
  • DRUG INEFFECTIVE54 reports
  • COUGH50 reports
  • HEADACHE46 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, And Phenylephrine Hydrochloride:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.