Acetaminophen Diphenhydramine Hcl: Uses, Side Effects, and Drug Interactions

Brand names: Pain Reliever PM Extra Strength

# Acetaminophen Diphenhydramine HCl Overview This medicine is a combination of two ingredients that work together to help you feel better when you're sick. Acetaminophen reduces fever and relieves pain, while diphenhydramine HCl helps dry up runny noses and reduce sneezing and watery eyes caused by colds or allergies. People use this medication when they have cold or flu symptoms and need relief from multiple problems at the same time. It's available over-the-counter, meaning you don't need a prescription to buy it at the pharmacy or drugstore. Before taking this medicine, there are some important safety rules to follow. Don't use it if you're allergic to either ingredient, and never give it to children under a certain age without talking to a doctor first. Be careful because this medicine can make you drowsy, so avoid driving or operating machinery after taking it. Don't use it for more than a few days in a row without asking your doctor, and always follow the dosage instructions on the package carefully. If you're pregnant, breastfeeding, or taking other medicines, check with your doctor or pharmacist first to make sure it's safe for you.

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Most Reported Side Effects (FAERS)

  • FATIGUE77 reports
  • NAUSEA60 reports
  • DRUG INEFFECTIVE54 reports
  • HEADACHE54 reports
  • DIARRHOEA48 reports
  • PAIN48 reports
  • DYSPNOEA45 reports
  • DIZZINESS37 reports
  • MALAISE35 reports
  • COUGH34 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.