Acetaminophen, Diphenhydramine Hcl, Phenylephrine Hcl: Uses, Side Effects, and Drug Interactions

Brand names: Maximum Strength Nighttime Cold and Flu

# Understanding This Cold and Flu Medicine This medication is a combination of three active ingredients that work together to help relieve cold and flu symptoms. Acetaminophen reduces fever and pain, diphenhydramine helps dry up congestion and makes you feel sleepy so you can rest, and phenylephrine helps clear your nasal passages so you can breathe easier. This medicine is designed to treat multiple symptoms at once, making it convenient when you have a cold or the flu with a runny nose, congestion, aches, fever, and sneezing. Before taking this medicine, it's important to know some safety rules. Don't use this medicine if you're allergic to any of its ingredients, and talk to a doctor before using it if you're pregnant, breastfeeding, or taking other medications. Because this medicine can make you drowsy, don't drive or operate machinery after taking it. Keep the medicine out of reach of children, store it at room temperature, and never take more than the recommended dose. If you accidentally take too much, contact Poison Control right away. Always read the label carefully and follow the directions for how much to take and how often to take it.

Taking Acetaminophen, Diphenhydramine Hcl, Phenylephrine Hcl with other medications?

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Most Reported Side Effects (FAERS)

  • FATIGUE49 reports
  • NAUSEA42 reports
  • DRUG INEFFECTIVE38 reports
  • DYSPNOEA36 reports
  • HEADACHE34 reports
  • DIARRHOEA33 reports
  • COUGH27 reports
  • PAIN27 reports
  • DIZZINESS26 reports
  • FEELING ABNORMAL24 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with Acetaminophen, Diphenhydramine Hcl, Phenylephrine Hcl:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.