Acetaminophen, Diphenhydramine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: Childrens Delsym Cough Plus Cold Night Time

# Acetaminophen and Diphenhydramine Hydrochloride Overview This medicine is a combination of two different drugs that work together to help you feel better. Acetaminophen reduces pain and fever, while diphenhydramine hydrochloride is an antihistamine that helps dry up cold and allergy symptoms. People use this medication to treat things like cold symptoms, allergies, and minor aches and pains. It can help with sneezing, runny nose, itchy eyes, and body aches all at the same time. Before taking this medicine, it's important to follow the safety rules. Don't use it if you're allergic to any ingredients, and always check with your doctor or pharmacist before using it if you're pregnant, nursing, or taking other medications. Never give this medicine to children under a certain age without asking a doctor first. Common side effects might include drowsiness and dry mouth. Stop using it and talk to a doctor if you have any unusual reactions. Always store the medicine at room temperature, away from heat and moisture, and keep it out of reach of children.

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Most Reported Side Effects (FAERS)

  • FATIGUE409 reports
  • NAUSEA336 reports
  • DIARRHOEA274 reports
  • DIZZINESS255 reports
  • HEADACHE239 reports
  • INSOMNIA239 reports
  • DRUG INEFFECTIVE230 reports
  • PAIN219 reports
  • ASTHENIA207 reports
  • DYSPNOEA201 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.