Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride: Uses, Side Effects, and Drug Interactions

Brand names: Cold plus Flu Congestion Severe

# Understanding This Medicine This medicine combines three ingredients to help you feel better when you have a cold or the flu. Acetaminophen reduces fever and pain, guaifenesin helps loosen mucus so you can cough it up more easily, and phenylephrine hydrochloride helps clear a stuffy nose. Together, these three medicines work to relieve multiple cold symptoms at the same time, making it easier to breathe and feel more comfortable while your body fights off the illness. Before taking this medicine, there are some important safety rules to follow. Never use it if you're allergic to any of the ingredients, and don't take it with other medicines that contain acetaminophen, since taking too much can damage your liver. Be careful if you have high blood pressure, heart problems, or thyroid issues—talk to your doctor first. Don't give this medicine to young children unless directed by a doctor, and if you're pregnant or breastfeeding, ask your doctor before using it. Stop taking it and call your doctor if you have any unusual side effects or if your symptoms don't improve after a few days.

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE16,740 reports
  • FATIGUE16,057 reports
  • HEADACHE12,974 reports
  • PAIN12,866 reports
  • NAUSEA12,614 reports
  • OFF LABEL USE11,842 reports
  • DIARRHOEA10,787 reports
  • ARTHRALGIA10,022 reports
  • DYSPNOEA9,779 reports
  • VOMITING7,361 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.