Acetaminophen, Ibuprofen: Uses, Side Effects, and Drug Interactions

Brand names: Dual Action Pain Relief

# Acetaminophen and Ibuprofen Overview This medicine combines two pain relievers that work together to help reduce pain and fever. Acetaminophen and ibuprofen are used to temporarily relieve minor aches and pains from headaches, muscle aches, backaches, minor arthritis pain, the common cold, toothaches, menstrual cramps, and the flu. Many people use this combination because the two ingredients work in different ways in your body, which can provide better relief than using just one ingredient alone. This medication is available over-the-counter, meaning you can buy it without a prescription. To use this medicine safely, always follow the directions on the package and never take more than the recommended dose. Do not use this medicine if you are allergic to acetaminophen, ibuprofen, or any ingredients in it, and be careful if you have stomach problems, heart disease, high blood pressure, or kidney disease. If you are pregnant, nursing a baby, or taking other medications, talk to your doctor or pharmacist before using this product. Stop taking the medicine and contact a doctor if you experience severe allergic reactions, unusual bruising or bleeding, or stomach pain. Keep this medication out of reach of children, and always store it at room temperature in a dry place.

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE56 reports
  • DRUG EFFECTIVE FOR UNAPPROVED INDICATION29 reports
  • THERAPEUTIC PRODUCT EFFECT INCOMPLETE29 reports
  • DRUG EFFECT LESS THAN EXPECTED15 reports
  • DIARRHOEA14 reports
  • OFF LABEL USE14 reports
  • FATIGUE13 reports
  • MALAISE13 reports
  • CONSTIPATION12 reports
  • OVERDOSE11 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Recent Recalls (1)

Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.

Check interactions with Acetaminophen, Ibuprofen:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.