Acetaminophen, Phenylephrine Hcl: Uses, Side Effects, and Drug Interactions

Brand names: Sinus Pressure and Pain

# Acetaminophen and Phenylephrine HCL Overview This medicine is a combination of two drugs that work together to help you feel better when you have a cold or the flu. Acetaminophen reduces fever and relieves pain, while phenylephrine HCL helps clear a stuffy nose by shrinking the blood vessels in your nasal passages. This combination makes it easier to breathe and reduces common cold symptoms like headaches, body aches, and congestion all at once. Before taking this medicine, there are some important safety rules to follow. Never take it if you're allergic to any of the ingredients, and don't use it with other pain relievers or fever reducers unless your doctor says it's okay. Talk to your doctor before using this medicine if you're pregnant, breastfeeding, or have heart problems, high blood pressure, or thyroid issues. Always follow the dosage instructions on the package carefully, keep it out of reach of children, and stop taking it and call your doctor if you have any unusual symptoms or if your condition doesn't improve after a few days.

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Most Reported Side Effects (FAERS)

  • PAIN8 reports
  • NAUSEA7 reports
  • PNEUMONIA6 reports
  • HEADACHE5 reports
  • SINUSITIS5 reports
  • ABDOMINAL PAIN UPPER4 reports
  • BACK PAIN4 reports
  • ACCIDENT3 reports
  • CONSTIPATION3 reports
  • COVID-193 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Recent Recalls (1)

Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.

Check interactions with Acetaminophen, Phenylephrine Hcl:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.