Adagrasib: Uses, Side Effects, and Drug Interactions

Brand names: KRAZATI

# Adagrasib Overview Adagrasib is a prescription medicine used to treat a specific type of lung cancer called non-small cell lung cancer (NSCLC) in patients whose cancer has a particular genetic change called a KRAS mutation. This drug works by blocking a protein that helps cancer cells grow and spread. It's designed for patients whose cancer has already been treated with other therapies and has stopped responding to them. Doctors will test your cancer cells to make sure you have the right type of mutation before prescribing this medicine. When taking adagrasib, it's important to be aware of some key safety points. The most common side effects include diarrhea, nausea, fatigue, and vomiting. You should avoid taking this medicine with certain other drugs because they can interact badly with adagrasib, making it less effective or causing harmful effects. Tell your doctor about all medications and supplements you're taking before starting treatment. If you're pregnant or planning to become pregnant, discuss this with your doctor, as this medicine may harm an unborn baby. Regular check-ups with your doctor are important to monitor how well the treatment is working and to watch for any side effects.

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Most Reported Side Effects (FAERS)

  • DEATH280 reports
  • DIARRHOEA116 reports
  • HOSPITALISATION108 reports
  • NAUSEA91 reports
  • VOMITING84 reports
  • OFF LABEL USE76 reports
  • ASTHENIA62 reports
  • FATIGUE52 reports
  • DECREASED APPETITE43 reports
  • DEHYDRATION35 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.