Adapalene: Uses, Side Effects, and Drug Interactions

Brand names: Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5%

# Adapalene Overview Adapalene is a medicine used to treat acne on the face. It works by helping your skin cells turn over faster and reducing swelling and redness caused by acne. You apply it directly to your skin as a gel or cream. Adapalene is especially helpful for people with mild to moderate acne who want to see clearer skin over time. Most people start noticing improvement after several weeks of regular use. When using adapalene, there are some important safety things to know. Your skin might feel dry, red, or irritated when you first start using it, which is normal. You should be careful if you're using other acne treatments at the same time, as this could make your skin even more irritated. Never use adapalene if you're allergic to it, and always tell your doctor if you're pregnant or nursing, since this medicine shouldn't be used during those times. Remember to use sunscreen every day while using adapalene because it can make your skin more sensitive to the sun.

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE51,446 reports
  • DRY SKIN45,196 reports
  • SKIN BURNING SENSATION41,850 reports
  • ACNE39,411 reports
  • ERYTHEMA38,659 reports
  • SKIN IRRITATION26,325 reports
  • SKIN EXFOLIATION21,386 reports
  • INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION16,208 reports
  • RASH15,598 reports
  • OVERDOSE13,219 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Recent Recalls (1)

Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.