amphetamine

Brand names: Amphetamine Sulfate

# Amphetamine: What You Need to Know Amphetamine is a prescription medicine used to treat attention-deficit/hyperactivity disorder (ADHD) and narcolepsy, a sleep disorder where people fall asleep unexpectedly during the day. The medication works by increasing activity in the brain, helping people with ADHD focus better and stay alert. For people with narcolepsy, it helps them stay awake. A doctor will decide if amphetamine is right for you based on your specific condition. This medicine comes with important safety warnings. Amphetamine can be habit-forming, so you should only take it exactly as your doctor prescribes. Tell your doctor about any other medications you take, especially antidepressants, because mixing amphetamine with certain drugs can be dangerous and cause serious health problems. You should also let your doctor know if you have heart problems, high blood pressure, or mental health issues, as amphetamine may not be safe for you. Common side effects include trouble sleeping, loss of appetite, and increased heart rate. Never share your medication with others, and contact your doctor immediately if you experience chest pain, severe headaches, or unusual changes in mood or behavior.

Known Interactions

Drug Interactions MAO inhibitors - MAOI antidepressants, as well as a metabolic of furazolidone, slow amphetamine metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings; this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results. Serotonergic drugs - The concomitant use of amphetamine sulfate tablets and serotonergic drugs increases the risk of serotonin syndrome. Initiate with lower doses and monitor patients for signs and symptoms of serotonin syndrome, particularly during amphetamine sulfate tablets initiation or dosage increase. If serotonin syndrome occurs, discontinue amphetamine sulfate tablets and the concomitant serotonergic drug(s) ( see WARNINGS and PRECAUTIONS ). CYP2D6 inhibitors - The concomitant use of amphetamine sulfate tablets and CYP2D6 inhibitors may in

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE5,046 reports
  • FATIGUE3,377 reports
  • NAUSEA3,029 reports
  • HEADACHE2,838 reports
  • ANXIETY2,619 reports
  • DEPRESSION2,215 reports
  • TOXICITY TO VARIOUS AGENTS2,198 reports
  • FEELING ABNORMAL2,100 reports
  • DRUG ABUSE1,897 reports
  • SOMNOLENCE1,871 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with amphetamine:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.