aripiprazole

Brand names: Aripiprazole

# Overview of Aripiprazole Aripiprazole is a prescription medicine used to treat certain mental health conditions. It helps people who have schizophrenia, bipolar disorder, or depression that doesn't get better with other medicines. Doctors also prescribe it for irritability in children with autism. This medication works by helping balance chemicals in the brain called neurotransmitters, which affect mood, thoughts, and behavior. When taking aripiprazole, it's important to know some safety information. This medicine can cause serious side effects in some people, which is why it comes with a boxed warning—the FDA's strongest safety alert. You should never stop taking this medicine suddenly without talking to your doctor first, even if you feel better. If you're taking other medications, tell your doctor because aripiprazole can interact with certain drugs, and your dose might need to be adjusted. It's especially important to mention this to your doctor if you're pregnant, planning to become pregnant, or taking other medicines that affect how your body processes aripiprazole.

Known Interactions

7 DRUG INTERACTIONS Dosage adjustment due to drug interactions (7.1): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Important Interactions with Aripiprazole Table 25: Clinically Important Drug Interactions with Aripiprazole: Concomitant Drug Name or Drug Class Clinical Rationale Clinical Recommendation Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin) or strong CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine) The concomitant use of aripiprazole with strong CYP 3A4 or CYP2D6 inhibitors increased the exposure of aripiprazole compared to the use of aripiprazole alone [see Clinical Pharmacology (1

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE8,306 reports
  • OFF LABEL USE8,299 reports
  • WEIGHT INCREASED7,873 reports
  • PRODUCT USE IN UNAPPROVED INDICATION5,252 reports
  • ANXIETY5,109 reports
  • FATIGUE4,318 reports
  • DEPRESSION4,051 reports
  • SUICIDAL IDEATION4,036 reports
  • NAUSEA3,974 reports
  • INSOMNIA3,890 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with aripiprazole:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.