canagliflozin

Brand names: INVOKANA

# Canagliflozin Overview Canagliflozin is a medicine used to help control blood sugar levels in adults with type 2 diabetes. It works by helping your kidneys remove extra sugar through your urine. Doctors often prescribe it along with other diabetes medicines and a healthy diet and exercise plan to help keep blood sugar at a safe level. This medication comes in tablet form and is taken by mouth once or twice a day, depending on your doctor's instructions. There are some important safety things to know about canagliflozin. You should not take this medicine if you are allergic to it or if you have serious kidney problems. While taking it, tell your doctor right away if you experience unusual symptoms like severe tiredness, trouble breathing, stomach pain, or nausea, as these could be signs of a serious condition. Also, let your doctor know about all other medicines you take, because some drugs can affect how well canagliflozin works in your body. Women who are pregnant or breastfeeding should talk to their doctor before taking this medicine to make sure it's safe for them and their baby.

Known Interactions

7 DRUG INTERACTIONS Table 7: Clinically Significant Drug Interactions with INVOKANA UGT Enzyme Inducers Clinical Impact: UGT enzyme inducers decrease canagliflozin exposure which may reduce the effectiveness of INVOKANA. Intervention: For patients with eGFR 60 mL/min/1.73 m 2 or greater, if an inducer of UGTs is administered with INVOKANA, increase the dosage to 200 mg daily in patients currently tolerating INVOKANA 100 mg daily. The total daily dosage may be increased to 300 mg daily in patients currently tolerating INVOKANA 200 mg daily who require additional glycemic control. For patients with eGFR less than 60 mL/min/1.73 m 2 , if an inducer of UGTs is administered with INVOKANA, increase the dosage to 200 mg daily in patients currently tolerating INVOKANA 100 mg daily. Consider adding another antihyperglycemic agent in patients who require additional glycemic control [see Dosage and Administration (2.3) and Clinical Pharmacology (12.3) ] . Examples: Rifampin, phenytoin, phenobarbi

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DIABETIC KETOACIDOSIS3,506 reports
  • TOE AMPUTATION2,263 reports
  • OSTEOMYELITIS2,231 reports
  • ACUTE KIDNEY INJURY2,030 reports
  • FUNGAL INFECTION1,489 reports
  • WEIGHT DECREASED1,402 reports
  • BLOOD GLUCOSE INCREASED1,295 reports
  • GANGRENE1,112 reports
  • NAUSEA1,071 reports
  • CELLULITIS1,063 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with canagliflozin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.