carvedilol

Brand names: Carvedilol

# Consumer Overview of Carvedilol Carvedilol is a medication that helps your heart work better and controls your blood pressure. Doctors prescribe it to treat high blood pressure and heart failure, which is when your heart doesn't pump blood as well as it should. This medicine belongs to a group of drugs called beta-blockers that help slow your heart rate and reduce the force of your heartbeat. By doing this, carvedilol makes it easier for your heart to pump blood throughout your body and lowers your blood pressure. Before taking carvedilol, it's important to tell your doctor about all other medicines you're taking, because this drug can interact with many other medications. For example, certain blood pressure medicines can cause dangerously low blood pressure or a heartbeat that's too slow when combined with carvedilol. Your doctor may need to adjust your doses or monitor you more carefully if you take other heart medications like digoxin or amiodarone. Always follow your doctor's directions exactly, take your doses as scheduled, and don't stop taking this medicine without talking to your doctor first, even if you start feeling better.

Known Interactions

7 DRUG INTERACTIONS CYP P450 2D6 enzyme inhibitors may increase and rifampin may decrease carvedilol levels. ( 7.1 , 7.5 ) Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. ( 7.4 ) Cyclosporine or digoxin levels may increase. ( 7.3 , 7.4 ) Both digitalis glycosides and β-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia. ( 7.4 ) Amiodarone may increase carvedilol levels resulting in further slowing of the heart rate or cardiac conduction. ( 7.6 ) Verapamil- or diltiazem-type calcium channel blockers may affect ECG and/or blood pressure. ( 7.7 ) Insulin and oral hypoglycemics action may be enhanced. ( 7.8 ) 7.1 CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to inc

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • FATIGUE8,890 reports
  • DYSPNOEA8,327 reports
  • DIZZINESS7,017 reports
  • DIARRHOEA6,972 reports
  • NAUSEA6,614 reports
  • DRUG INEFFECTIVE5,890 reports
  • DEATH5,700 reports
  • HYPOTENSION5,685 reports
  • ASTHENIA5,421 reports
  • CARDIAC FAILURE CONGESTIVE4,477 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with carvedilol:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.