celecoxib

Brand names: CELECOXIB

# Celecoxib: What You Need to Know Celecoxib is a medicine used to reduce pain and swelling caused by conditions like arthritis, menstrual cramps, and other injuries. It belongs to a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs) that work by lowering chemicals in your body that cause pain and inflammation. Doctors prescribe it when other pain relievers haven't worked well enough or when patients need stronger relief from ongoing pain. Before taking celecoxib, it's important to know some safety facts. You should not take this medicine if you're allergic to it or if you take blood thinners like warfarin, because combining them can increase your risk of serious bleeding. Celecoxib can also cause stomach problems, heart issues, and kidney damage in some people, especially if you take it for a long time or have certain health conditions. Always tell your doctor about any other medicines you're taking and any health problems you have. This medicine works best when taken exactly as your doctor prescribes, and you should use the lowest dose for the shortest amount of time needed.

Known Interactions

7. DRUG INTERACTIONS See Table 3 for clinically significant drug interactions with celecoxib. Table 3: Clinically Significant Drug Interactions with Celecoxib Drugs That Interfere with Hemostasis Clinical Impact: Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. Intervention: Monitor patients with concomitant use of celecoxib with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see Warnings and Precautions (5.12) ]. Aspirin Clinical Impact: Controlled clinical studies showed that the concomita

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE17,635 reports
  • PAIN12,294 reports
  • ARTHRALGIA10,924 reports
  • FATIGUE9,708 reports
  • NAUSEA9,387 reports
  • DRUG HYPERSENSITIVITY7,714 reports
  • OFF LABEL USE7,651 reports
  • DIARRHOEA7,296 reports
  • HEADACHE7,229 reports
  • RHEUMATOID ARTHRITIS7,200 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with celecoxib:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.