dapagliflozin

Brand names: FARXIGA

# Dapagliflozin Overview Dapagliflozin is a medication used to help control blood sugar levels in people with type 2 diabetes. It works by helping your kidneys remove extra sugar through your urine. This medicine can help reduce the risk of serious health problems that can happen when blood sugar stays too high for a long time. Doctors may also prescribe it to help protect the heart and kidneys in people with certain heart or kidney conditions. When taking dapagliflozin, it's important to know some safety information. If you take it with insulin or other diabetes medicines that lower blood sugar, you may have a greater chance of your blood sugar dropping too low, so your doctor might need to adjust your other medicines. You should also tell your doctor about all the medicines you take, especially lithium, since dapagliflozin can interact with other drugs. Always follow your doctor's instructions about how much to take and when, and report any unusual side effects right away.

Known Interactions

7 DRUG INTERACTIONS Table 5: Clinically Relevant Interactions with FARXIGA Insulin or Insulin Secretagogues Clinical Impact The risk of hypoglycemia may be increased when FARXIGA is used concomitantly with insulin or insulin secretagogues (e.g., sulfonylurea) [see Warnings and Precautions (5.4) ] . Intervention Concomitant use may require lower doses of insulin or the insulin secretagogue to reduce the risk of hypoglycemia. Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during FARXIGA initiation and dosage changes. Positive Urine Glucose Test Clinical Impact SGLT2 inhibitors increase urinary glucose excretion and will lead to positive urine glucose tests. Intervention Monitoring glycemic control with urine glucose tests is not recommended in patients taking SGLT2 inhibitors. Use alternative methods to monitor glycemic control. Interference with 1,5-anh

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DEATH7,135 reports
  • NAUSEA2,405 reports
  • FATIGUE2,379 reports
  • DIARRHOEA2,208 reports
  • DIZZINESS2,194 reports
  • BLOOD GLUCOSE INCREASED2,067 reports
  • DYSPNOEA2,029 reports
  • WEIGHT DECREASED1,978 reports
  • OFF LABEL USE1,863 reports
  • ACUTE KIDNEY INJURY1,772 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with dapagliflozin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.