doxazosin

Brand names: Doxazosin

# Doxazosin Overview Doxazosin is a medication used to treat high blood pressure and to help men with urinary problems caused by an enlarged prostate gland. It works by relaxing blood vessels and muscles in the prostate, allowing blood to flow more easily and making it easier to urinate. Doctors may prescribe this medicine as part of a treatment plan to help control these conditions. It comes in tablet form and is usually taken once a day, often in the evening. There are some important safety things to know about doxazosin. It can lower your blood pressure, which might make you feel dizzy or lightheaded, especially when you first start taking it or when the dose changes. You should avoid taking this medicine with certain other drugs, particularly medications used to treat erectile dysfunction (like Viagra) or other medications that affect how your body processes doxazosin, because these combinations can cause dangerous drops in blood pressure. Always tell your doctor about all medicines you're taking, and don't stop taking doxazosin without talking to your doctor first.

Known Interactions

7 DRUG INTERACTIONS • Strong cytochrome P450 (CYP) 3A inhibitors may increase exposure to doxazosin and increased risk of hypotension. ( 7.1 ) • Concomitant administration of doxazosin tablets with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension. ( 7.2 ) 7.1 CYP 3A Inhibitors In vitro studies suggest that doxazosin is a substrate of CYP 3A4. Strong CYP3A inhibitors may increase exposure to doxazosin. Monitor blood pressure and for symptoms of hypotension when doxazosin tablets are used concomitantly with strong CYP3A inhibitors [ see Clinical Pharmacology ( 12.3 ) ]. 7.2 Phosphodiesterase-5 (PDE-5) Inhibitors Concomitant administration of doxazosin tablets with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension. Monitor blood pressure and for symptoms of hypotension [ see Warnings and Precautions ( 5.1 ) ].

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DYSPNOEA1,937 reports
  • DIZZINESS1,686 reports
  • FATIGUE1,682 reports
  • DIARRHOEA1,625 reports
  • DRUG INEFFECTIVE1,570 reports
  • NAUSEA1,431 reports
  • HYPOTENSION1,291 reports
  • ASTHENIA1,258 reports
  • ACUTE KIDNEY INJURY1,224 reports
  • HEADACHE1,200 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with doxazosin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.