Famotidine: Uses, Side Effects, and Drug Interactions
Brand names: Famotidine
# Famotidine Overview Famotidine is a medication used to treat heartburn, acid reflux, and stomach ulcers. It works by reducing the amount of acid your stomach produces, which helps relieve the burning feeling in your chest and throat caused by acid reflux. People also use it to prevent ulcers and to treat conditions where the stomach makes too much acid. You can buy famotidine over-the-counter at lower doses, or your doctor can prescribe stronger doses if you need them for more serious conditions. Before taking famotidine, it's important to tell your doctor about any other medicines you're taking, especially a muscle relaxer called tizanidine, because famotidine can make that drug build up dangerously in your body. Also, famotidine can change how your stomach absorbs certain other medications, so some drugs may not work as well when taken together. If you have kidney problems or are pregnant, talk to your doctor before using this medication. Most people tolerate famotidine well with few side effects, but always follow the dosage instructions on the package or from your doctor to use it safely.
Known Interactions (2)
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Check Now ↓Most Reported Side Effects (FAERS)
- NAUSEA7,344 reports
- FATIGUE6,912 reports
- CHRONIC KIDNEY DISEASE6,777 reports
- DIARRHOEA6,522 reports
- DRUG INEFFECTIVE6,444 reports
- OFF LABEL USE5,317 reports
- DYSPNOEA5,235 reports
- HEADACHE4,970 reports
- ACUTE KIDNEY INJURY4,734 reports
- PAIN4,656 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (2)
- Class I
Fresenius Kabi USA, LLC · November 6, 2025
Famotidine Injection, USP, 20 mg per 2 mL (10 mg per mL), 2 mL vials, Rx only, Fresenius Kabi USA, LLC, NDC 63323-739-11 (unit of use), 63323-739-12 (unit of sale).Microbial Contamination of Sterile Products; out of limit results obtained for endotoxin testing.
- Class II
Ascend Laboratories, LLC · December 29, 2023
Ibuprofen and Famotidine Tablets 800mg/26.6mg, Rx Only, 90 Tablets per Bottle, manufactured by: Alkem Laboratories Ltd., INDIA, Distributed by: Ascend Laboratories, LLC., Parsippany, NJ 07054, NDC 678Presence of Foreign Tablet/Capsule: A stray Rasagiline Mesylate 1 mg tablet was discovered in an unopened bottle of Ibuprofen and Famotidine.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.