glimepiride

Brand names: Glimepiride

# Understanding Glimepiride Glimepiride is a medication used to help control blood sugar levels in people with type 2 diabetes. It works by helping your pancreas release more insulin, which is the hormone your body uses to manage blood sugar. This medicine is usually taken by mouth once a day, typically with breakfast or your first meal. Doctors prescribe glimepiride when diet and exercise alone aren't enough to keep blood sugar under control. It comes in tablet form in different strengths, so your doctor can find the right dose for you. While glimepiride can be very helpful for managing diabetes, there are some important safety things to know. Taking this medicine can sometimes cause your blood sugar to drop too low, which is called hypoglycemia. You should never take glimepiride with the antifungal medication miconazole because it greatly increases this risk. Also, certain other medicines can change how glimepiride works in your body, so always tell your doctor about all medications and supplements you take. Your blood sugar will need to be monitored regularly, and pregnant women should not use this medication since it could harm a developing baby.

Known Interactions

7 DRUG INTERACTIONS Certain medications may affect glucose metabolism, requiring glimepiride tablets dose adjustment and close monitoring of blood glucose ( 7.1 ). Miconazole: Severe hypoglycemia can occur when glimepiride and oral miconazole are used concomitantly. ( 7.2 ). Cytochrome P450 2C9 interactions: Inhibitors and inducers of cytochrome P450 2C9 may affect glycemic control by altering glimepiride plasma concentrations ( 7.3 ). Colesevelam: Coadministration may reduce glimepiride absorption. Glimepiride should be administered at least 4 hours prior to colesevelam ( 2.1 , 7.4 ). 7.1 Drugs Affecting Glucose Metabolism A number of medications affect glucose metabolism and may require glimepiride tablets dose adjustment and particularly close monitoring for hypoglycemia or worsening glycemic control. The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hyp

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • BLOOD GLUCOSE INCREASED2,979 reports
  • NAUSEA2,282 reports
  • DIARRHOEA2,173 reports
  • DRUG INEFFECTIVE1,924 reports
  • FATIGUE1,830 reports
  • HYPOGLYCAEMIA1,642 reports
  • WEIGHT DECREASED1,395 reports
  • DIZZINESS1,370 reports
  • DYSPNOEA1,325 reports
  • VOMITING1,293 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with glimepiride:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.