glipizide

Brand names: Glipizide

# Glipizide: What You Need to Know Glipizide is a medicine used to help control blood sugar levels in people with type 2 diabetes. It works by telling your pancreas to release more insulin, which helps your body use sugar properly. This medication is usually prescribed when diet and exercise alone aren't enough to keep blood sugar under control. Doctors often combine glipizide with other diabetes medicines to help patients manage their condition more effectively. Since glipizide makes your body produce more insulin, one important safety concern is low blood sugar (hypoglycemia). This risk increases if you take certain other medications at the same time, including pain relievers like ibuprofen, some antibiotics, and blood thinners. If you start or stop taking any other medicines while using glipizide, it's crucial to tell your doctor so they can monitor your blood sugar levels closely. Watch for warning signs of low blood sugar like shakiness, sweating, confusion, or rapid heartbeat, and always keep a source of fast-acting sugar nearby just in case.

Known Interactions

Drug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including non-steroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, quinolones and beta-adrenergic blocking agents. When such drugs are administered to a patient receiving glipizide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for loss of control. In vitro binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of glipizide with these drugs. Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include th

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • BLOOD GLUCOSE INCREASED6,679 reports
  • NAUSEA4,445 reports
  • DRUG INEFFECTIVE3,510 reports
  • DIARRHOEA3,270 reports
  • FATIGUE2,999 reports
  • WEIGHT DECREASED2,811 reports
  • DIZZINESS2,444 reports
  • DYSPNOEA2,405 reports
  • BLOOD GLUCOSE DECREASED2,231 reports
  • VOMITING2,168 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with glipizide:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.