indomethacin

Brand names: Indomethacin

# Overview of Indomethacin Indomethacin is a pain-relieving medicine that belongs to a group of drugs called NSAIDs (non-steroidal anti-inflammatory drugs). Doctors prescribe it to reduce pain, swelling, and stiffness caused by conditions like arthritis and other inflammatory diseases. It works by blocking chemicals in your body that cause inflammation and pain. This medication comes in different forms, including capsules and liquids, and can help people feel better and move more easily when they're dealing with joint or muscle problems. While indomethacin can be helpful, it's important to use it safely. This medicine can increase your risk of serious stomach problems, bleeding, and heart issues, especially if you take it for a long time or if you're older. You should never mix indomethacin with blood-thinning medicines like warfarin without talking to your doctor first, since this combination increases your risk of dangerous bleeding. Always take indomethacin exactly as your doctor tells you, use the lowest dose that works for you, and talk to your doctor right away if you notice any unusual symptoms like stomach pain, black stools, shortness of breath, or chest pain.

Known Interactions

7 DRUG INTERACTIONS See Table 2 for clinically significant drug interactions with indomethacin. Table 2 Clinically Significant Drug Interactions with Indomethacin Drugs That Interfere with Hemostasis Clinical Impact: Indomethacin and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of indomethacin and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. Intervention: Monitor patients with concomitant use of indomethacin capsules with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [ see

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE1,371 reports
  • FATIGUE1,102 reports
  • ARTHRALGIA1,002 reports
  • HEADACHE990 reports
  • OFF LABEL USE939 reports
  • PAIN922 reports
  • NAUSEA907 reports
  • DIARRHOEA878 reports
  • DIZZINESS868 reports
  • DYSPNOEA744 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with indomethacin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.