isosorbide mononitrate

Brand names: Isosorbide Mononitrate

# Isosorbide Mononitrate: What You Need to Know Isosorbide mononitrate is a medication used to prevent chest pain (angina) in people with heart problems. It works by relaxing blood vessels and improving blood flow to the heart, which helps reduce the pain and pressure you might feel in your chest. This medicine is usually taken by mouth as a tablet or capsule and comes in different strengths depending on what your doctor prescribes. There are some important safety rules to follow when taking this medication. You should never combine it with certain other drugs, especially medications for erectile dysfunction (like Viagra) or alcohol, because these can cause dangerous drops in blood pressure. Always tell your doctor about all other medicines you're taking and any health conditions you have. If you experience severe dizziness, fainting, or unusually fast heartbeats while taking this drug, contact your doctor right away. Taking this medication exactly as prescribed and at regular times each day will help it work best to prevent chest pain and keep your heart healthier.

Known Interactions

Drug Interactions Concomitant use of isosorbide mononitrate with phosphodiesterase inhibitors in any form is contraindicated (see CONTRAINDICATIONS ). Concomitant use of isosorbide mononitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated (see CONTRAINDICATIONS ). The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety. Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DYSPNOEA1,505 reports
  • DIZZINESS1,397 reports
  • DIARRHOEA1,249 reports
  • FATIGUE1,243 reports
  • NAUSEA1,231 reports
  • CHEST PAIN1,185 reports
  • MYOCARDIAL INFARCTION1,020 reports
  • HEADACHE1,000 reports
  • VOMITING942 reports
  • HYPOTENSION901 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with isosorbide mononitrate:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.