lamotrigine
Brand names: Lamotrigine
# Lamotrigine Overview Lamotrigine is a medicine that doctors prescribe to treat epilepsy (a condition that causes seizures) and bipolar disorder (a mental health condition with extreme mood changes). It works by calming overactive electrical activity in the brain. The medicine comes in different forms and strengths, and your doctor will decide the right dose for you based on your specific condition and other medicines you might be taking. There are some important safety things to know about lamotrigine. One serious warning is that it can cause a dangerous skin rash, especially in children and when starting treatment. You should contact your doctor right away if you develop any unusual rash or skin problems. Additionally, lamotrigine can interact with other medications, meaning they might affect how well each medicine works or increase side effects. Always tell your doctor about every medicine, supplement, or herb you're taking. Like all medicines, lamotrigine can cause side effects, so it's important to discuss any concerns with your healthcare provider and follow their instructions carefully.
Known Interactions
7 DRUG INTERACTIONS Significant drug interactions with lamotrigine are summarized in this section. Uridine 5´-diphospho-glucuronyl transferases (UGT) have been identified as the enzymes responsible for metabolism of lamotrigine. Drugs that induce or inhibit glucuronidation may, therefore, affect the apparent clearance of lamotrigine. Strong or moderate inducers of the cytochrome P450 3A4 (CYP3A4) enzyme, which are also known to induce UGT, may also enhance the metabolism of lamotrigine. Those drugs that have been demonstrated to have a clinically significant impact on lamotrigine metabolism are outlined in Table 13. Specific dosing guidance for these drugs is provided in the Dosage and Administration section [see Dosage and Administration (2.1) ] . Additional details of these drug interaction studies are provided in the Clinical Pharmacology section [see Clinical Pharmacology (12.3) ] . Table 13. Established and Other Potentially Significant Drug Interactions Concomitant Drug Effect on
Source: FDA-approved drug labeling via openFDA
Most Reported Side Effects (FAERS)
- DRUG INEFFECTIVE9,924 reports
- RASH8,411 reports
- SEIZURE6,541 reports
- NAUSEA6,157 reports
- FATIGUE5,925 reports
- OFF LABEL USE5,835 reports
- DIZZINESS5,777 reports
- HEADACHE5,569 reports
- DEPRESSION4,964 reports
- VOMITING4,550 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Check interactions with lamotrigine:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.