Levothyroxine: Uses, Side Effects, and Drug Interactions
Brand names: Levothyroxine sodium
# Levothyroxine Overview Levothyroxine is a medicine used to treat an underactive thyroid gland, a condition called hypothyroidism. When your thyroid doesn't make enough thyroid hormone, your body's metabolism slows down and you may feel tired, gain weight, or feel cold. Levothyroxine is a man-made version of thyroid hormone that replaces what your body isn't making. It helps your body work at the right speed and feel normal again. This medication is usually taken as a pill by mouth and needs to be taken regularly to work properly. It's important to take levothyroxine safely by following your doctor's instructions carefully. Many other medicines can change how levothyroxine works in your body, so always tell your doctor and pharmacist about all the medications you're taking before starting levothyroxine. Your doctor will need to check your blood regularly to make sure you're taking the right dose—too much or too little can cause problems. Always take levothyroxine exactly as prescribed and don't change your dose without talking to your doctor first.
Known Interactions (8)
Taking Levothyroxine with other medications?
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Check Now ↓Most Reported Side Effects (FAERS)
- FATIGUE25,855 reports
- NAUSEA22,040 reports
- DRUG INEFFECTIVE20,567 reports
- HEADACHE18,800 reports
- DIARRHOEA18,179 reports
- DYSPNOEA16,220 reports
- PAIN15,941 reports
- DIZZINESS15,431 reports
- ASTHENIA13,164 reports
- ARTHRALGIA12,990 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (5)
- Class II
Alvogen, Inc · December 31, 2025
Levothyroxine Sodium Tablets, USP, Thyro-Tabs, 150mcg, 1000 Tablets, Rx only, Manufactured by: LLOYD, Inc., Shenandoah, IA, 51601 USA, Distributed by: Alvogen, Inc., Pine Brook, NJ 07058 USA, NDC: 477Product Mix-Up: A single bottle of this lot was reported by a pharmacy to contain 88 mcg tablets instead of 150 mcg tablets.
- Class II
ACCORD HEALTHCARE, INC. · September 16, 2025
Levothyroxine Sodium Tablets, USP, 88 mcg (0.088 mg), 90 Tablets per bottle, Rx Only, Manufactured for Accord Healthcare, Inc., Raleigh, NC 27617, Manufactured by: Intas Pharmaceuticals Limited, CampSubpotent: During long term stability testing of Levothyroxine Sodium Tablets USP for 88 mcg, the assay content was observed below the approved specification range.
- Class II
ACCORD HEALTHCARE, INC. · June 20, 2025
Levothyroxine Sodium Tablets, USP, 50 mcg (0.05 mg), 90-count bottle, Rx Only, Manufactured for: Accord Healthcare, Inc., Raleigh, NC 27617, Manufactured by: Intas Pharmaceuticals Limited, Camp Road,Subpotent Drug: Assay below the approved specification
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Supplement Interactions (2)
These dietary supplements may interact with Levothyroxine. Always consult your healthcare provider.
- moderatecalcium
Calcium reduces absorption of thyroid hormone replacement.
Separate doses by at least 4 hours.
- moderate
Check interactions with Levothyroxine:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.