Lisinopril: Uses, Side Effects, and Drug Interactions
Brand names: Lisinopril and Hydrochlorothiazide
# Lisinopril: What You Should Know Lisinopril is a medicine used to help control high blood pressure and treat heart problems. It works by relaxing blood vessels so blood can flow more easily through your body, which lowers your blood pressure. Doctors may prescribe this medicine to patients whose hearts aren't pumping as well as they should, or to help prevent heart damage. It's an important medication that helps reduce the risk of heart attacks and strokes by keeping your blood pressure at a healthy level. While lisinopril is helpful for many people, there are some important safety things to know. You should tell your doctor about all other medicines you take, especially water pills (diuretics), because taking lisinopril with these can sometimes cause your blood pressure to drop too low. Common side effects include dizziness, tiredness, or a dry cough—most of these are mild. You shouldn't take lisinopril if you're pregnant, as it can harm your baby. It's important to take this medicine exactly as your doctor prescribes, check your blood pressure regularly, and talk to your doctor before stopping the medication or making any changes.
Known Interactions (8)
Taking Lisinopril with other medications?
Check Lisinopril against any other medication — the form below is already pre-filled.
Check Now ↓Most Reported Side Effects (FAERS)
- FATIGUE19,929 reports
- NAUSEA18,606 reports
- DRUG INEFFECTIVE17,692 reports
- DIARRHOEA17,298 reports
- DYSPNOEA14,032 reports
- PAIN13,723 reports
- DIZZINESS13,631 reports
- HEADACHE12,998 reports
- ASTHENIA10,998 reports
- VOMITING10,936 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (3)
- Class II
Lupin Pharmaceuticals Inc. · June 20, 2025
Lisinopril and Hydrochlorothiazide Tablets USP 20mg/12.5mg, 100-count bottles, Rx only, Mfg for: Lupin Pharmaceuticals, Inc. Baltimore, MD 21202, Manufactured by: Lupin Limited Nagpur-441 108, INDIA,Product Mix Up: This product is being recalled because of a complaint received that a sealed bottle of lisinopril and hydrochlorothiazide tablets 20mg/12.5 mg had a foreign tablet identified as atazanavir and ritonavir tablet 300mg/100mg.
- Class II
Evaric Pharmaceuticals Inc. · November 15, 2024
Lisinopril Tablets, USP 10 mg, 90 tablets per bottle, Rx Only, Distributed by: Walmart, Bentonville, AR 72716, Manufactured for: Camber Pharmaceuticals, Inc., Piscataway, NJ 08854, Packaged by: LegacyPresence of Foreign Object: A pharmacist discovered a metal fragment embedded in a lisinopril 10 mg tablet.
- Class II
CARDINAL HEALTHCARE · January 26, 2022
Lisinopril and Hydrochlorothiazide Tablets USP, 10mg/12.5mg, Rx only, 100 Tablets per bottles, Manufactured for: Lupin Pharmaceuticals, Inc., Baltimore, Maryland 21202; Manufactured by: Lupin Limited,CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Supplement Interactions (1)
These dietary supplements may interact with Lisinopril. Always consult your healthcare provider.
- mildmelatonin
Melatonin may enhance the blood pressure-lowering effect of antihypertensives.
Monitor blood pressure when starting melatonin.
Check interactions with Lisinopril:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.