losartan

Brand names: Losartan Potassium

# Losartan Overview Losartan is a medicine used to treat high blood pressure and to help protect your kidneys if you have diabetes. When your blood pressure is too high, it can damage your heart and other organs. Losartan works by relaxing your blood vessels so blood can flow more easily through them. This helps lower your blood pressure and makes it easier for your heart to pump blood. By keeping your blood pressure under control, losartan helps prevent serious health problems like heart attacks and strokes. Like all medicines, losartan can interact with other drugs, so it's important to tell your doctor about everything you're taking. You should be careful when taking other medicines that can raise potassium levels in your blood, because losartan can increase potassium too. You also need to be careful if you take non-steroidal anti-inflammatory drugs (like ibuprofen), the medicine lithium, or other blood pressure medications, as these can cause problems when combined with losartan. Your doctor will make sure losartan is safe for you and watch you carefully while you take it to make sure it's working properly and not causing any bad side effects.

Known Interactions

7 DRUG INTERACTIONS • Agents Increasing Serum Potassium: Risk of hyperkalemia. (7.1) • Lithium: Risk of lithium toxicity. (7.2) • NSAIDs: Increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. (7.3) • Dual Inhibition of the Renin-Angiotensin System: Increased risk of renal impairment, hypotension, syncope, and hyperkalemia. (7.4) 7.1 Agents Increasing Serum Potassium Coadministration of losartan with other drugs that raise serum potassium levels may result in hyperkalemia. Monitor serum potassium in such patients. 7.2 Lithium Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists. Monitor serum lithium levels during concomitant use. 7.3 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy),

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • FATIGUE13,967 reports
  • DIARRHOEA11,700 reports
  • NAUSEA11,513 reports
  • DRUG INEFFECTIVE11,292 reports
  • DYSPNOEA10,379 reports
  • DIZZINESS9,895 reports
  • HEADACHE9,457 reports
  • PAIN8,871 reports
  • OFF LABEL USE7,929 reports
  • ARTHRALGIA7,572 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with losartan:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.