methotrexate

Brand names: METHOTREXATE

# Understanding Methotrexate Methotrexate is a medication used to treat several different health conditions, including certain types of cancer, autoimmune diseases like rheumatoid arthritis, and some skin conditions. It works by slowing down or stopping the growth of rapidly dividing cells in your body. Depending on the condition being treated, your doctor may give it as an injection, pill, or intravenous infusion. The dose and frequency will depend on what condition you're being treated for and your individual health needs. Because methotrexate is a powerful medication, it's important to take it exactly as your doctor prescribes and attend all follow-up appointments. You should always tell your doctor about any other medications or supplements you're taking, since some drugs can increase the amount of methotrexate in your body and make side effects more serious. Common side effects may include nausea, tiredness, and mouth sores. You should never take methotrexate if you're pregnant or planning to become pregnant, as it can harm an unborn baby. Always contact your doctor immediately if you experience severe symptoms like unusual bruising, signs of infection, or severe stomach pain.

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE92,075 reports
  • RHEUMATOID ARTHRITIS42,189 reports
  • ARTHRALGIA40,160 reports
  • PAIN39,087 reports
  • OFF LABEL USE38,632 reports
  • FATIGUE32,435 reports
  • NAUSEA28,460 reports
  • JOINT SWELLING24,646 reports
  • DRUG INTOLERANCE24,004 reports
  • CONDITION AGGRAVATED23,305 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.