metoprolol

Brand names: Metoprolol Tartrate

# Metoprolol: What You Need to Know Metoprolol is a medication called a beta-blocker that helps treat high blood pressure and heart problems. It works by slowing down your heart rate and making your heart pump with less force, which takes pressure off your blood vessels. This helps your heart work more efficiently and can prevent serious health issues like heart attacks and strokes. Your doctor might prescribe metoprolol if you have high blood pressure, chest pain, or a weak heart. Like all medicines, metoprolol can interact with other drugs and has some important safety rules. You should never stop taking it suddenly without talking to your doctor, as this can cause serious problems. Be careful if you're taking other heart medications, as metoprolol can interact with them and slow your heart rate too much. If you have an allergic reaction, tell emergency responders you're taking metoprolol because it might affect how certain emergency medicines work. Always tell your doctor about all other medicines and supplements you take, and follow the dosage instructions exactly as prescribed.

Known Interactions

7 DRUG INTERACTIONS Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. ( 7.1 ) Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. ( 7.2 ) CYP2D6 Inhibitors are likely to increase metoprolol concentration. ( 7.3 ) Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. ( 7.4 ) Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine. ( 7.4 ) 7.1 Catecholamine Depleting Drugs Catecholamine depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) may have an additive effect when given with beta-blocking agents. Observe patients treated with metoprolol plus a catecholamine depletor for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. 7.2 Epinephrine While taking beta-blockers, patients with a histor

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • FATIGUE22,536 reports
  • DYSPNOEA19,528 reports
  • DIARRHOEA19,148 reports
  • NAUSEA18,957 reports
  • DRUG INEFFECTIVE17,046 reports
  • DIZZINESS16,171 reports
  • OFF LABEL USE14,092 reports
  • DEATH13,701 reports
  • ASTHENIA13,099 reports
  • PAIN12,868 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with metoprolol:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.