Ondansetron: Uses, Side Effects, and Drug Interactions
Brand names: ondansetron hydrochloride
# Overview of Ondansetron Ondansetron is a medicine used to prevent and treat nausea and vomiting in patients, especially those receiving chemotherapy, radiation therapy, or recovering from surgery. It works by blocking chemicals in the body that trigger the feeling of nausea. This medication can help patients feel more comfortable during medical treatments and recover better after procedures. Ondansetron comes in different forms, including tablets and liquids, making it easy for doctors to prescribe the right dose for each patient. While ondansetron is generally safe and effective, there are some important safety points to know. You should tell your doctor about all other medicines you take, because ondansetron can interact with certain drugs, especially those used to treat depression or anxiety. In rare cases, taking ondansetron with these medicines together could cause a serious condition called serotonin syndrome, which involves confusion, rapid heartbeat, and muscle stiffness. If you experience unusual symptoms after taking this medicine, contact your doctor right away. Always take ondansetron exactly as prescribed and report any side effects to your healthcare provider.
Taking Ondansetron with other medications?
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Check Now ↓Most Reported Side Effects (FAERS)
- NAUSEA13,439 reports
- FATIGUE9,377 reports
- DIARRHOEA8,859 reports
- VOMITING8,286 reports
- OFF LABEL USE7,373 reports
- DYSPNOEA5,566 reports
- PYREXIA5,366 reports
- DEATH5,331 reports
- HEADACHE5,225 reports
- PAIN5,178 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (1)
- Class II
Glenmark Pharmaceuticals Inc., USA · December 30, 2025
Ondansetron Orally Disintegrating Tablets, USP, 4mg, 30 Tablets (3 blistercards each containing 10 tablets), Rx only, Manufactured for: Glenmark Pharmaceuticals Inc., USA Mahwah, NJ 07430, Product ofDefective container: Preferred Pharmaceuticals received a letter from the manufacturer Glenmark, that the blister packs are not fully sealed and tablets falling out. Preferred Pharmaceuticals purchased the finished product and repackaged the product for sale.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Check interactions with Ondansetron:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.