pregabalin

Brand names: PREGABALIN

# Understanding Pregabalin Pregabalin is a prescription medicine used to treat several types of pain and nerve problems. Doctors prescribe it for nerve pain caused by diabetes, shingles, or spinal cord injuries. It's also used to treat fibromyalgia, which causes widespread muscle pain and tiredness. Additionally, pregabalin can help control seizures in people with epilepsy and reduce anxiety in certain conditions. The medication works by calming overactive nerves in your body that send pain signals to your brain. Like all medicines, pregabalin can cause side effects and has some important safety information you should know. Common side effects include dizziness, drowsiness, and weight gain. Since pregabalin can make you dizzy and drowsy, don't drive or operate machinery until you know how it affects you. It's important to take this medicine exactly as your doctor prescribed and not suddenly stop taking it without talking to your doctor first. Let your doctor know about all other medicines you're taking, since pregabalin doesn't interact much with other drugs because your body doesn't break it down like many other medicines do. If you have kidney problems, tell your doctor, as your dose may need to be adjusted.

Known Interactions

7 DRUG INTERACTIONS Since pregabalin is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans (less than 2% of a dose recovered in urine as metabolites), and does not bind to plasma proteins, its pharmacokinetics are unlikely to be affected by other agents through metabolic interactions or protein binding displacement. In vitro and in vivo studies showed that pregabalin is unlikely to be involved in significant pharmacokinetic drug interactions. Specifically, there are no pharmacokinetic interactions between pregabalin and the following antiepileptic drugs: carbamazepine, valproic acid, lamotrigine, phenytoin, phenobarbital, and topiramate. Important pharmacokinetic interactions would also not be expected to occur between pregabalin and commonly used antiepileptic drugs [see Clinical Pharmacology (12) ] . Pharmacodynamics Multiple oral doses of pregabalin were co-administered with oxycodone, lorazepam, or ethanol. Although no pharmacokinetic interacti

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE26,492 reports
  • PAIN25,903 reports
  • FATIGUE15,111 reports
  • DIZZINESS14,524 reports
  • NAUSEA14,054 reports
  • OFF LABEL USE13,250 reports
  • HEADACHE12,682 reports
  • MALAISE12,592 reports
  • SOMNOLENCE11,568 reports
  • WEIGHT INCREASED11,411 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with pregabalin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.