propranolol

Brand names: Propranolol Hydrochloride

# Propranolol: What You Need to Know Propranolol is a medicine called a beta-blocker that helps your body control heart rate and blood pressure. Doctors prescribe it to treat several conditions, including high blood pressure, chest pain, and irregular heartbeats. It can also help prevent migraines and reduce physical symptoms of anxiety, like shaking or a racing heart. Propranolol works by helping your heart beat more slowly and with less force, which takes pressure off your blood vessels and makes it easier for blood to flow through your body. If you take propranolol, it's important to know some safety tips. Always tell your doctor about other medicines you take, since propranolol can interact with many drugs and change how they work in your body. Never stop taking propranolol suddenly—your doctor needs to slowly reduce your dose to avoid serious heart problems. Be careful if you have asthma, diabetes, or liver problems, since propranolol may make these conditions harder to manage. Like all medicines, propranolol can cause side effects, so talk to your doctor if you feel dizzy, tired, or experience any unusual symptoms while taking it.

Known Interactions

Drug Interactions Caution should be exercised when propranolol is administered with drugs that have an effect on CYP2D6, 1A2, or 2C19 metabolic pathways. Co-administration of such drugs with propranolol may lead to clinically relevant drug interactions and changes on its efficacy and/or toxicity (see Drug Interactions in PHARMACOKINETICS AND DRUG METABOLISM ). Cardiovascular Drugs Antiarrhythmics Propafenone has negative inotropic and beta-blocking properties that can be additive to those of propranolol. Quinidine increases the concentration of propranolol and produces greater degrees of clinical beta-blockade and may cause postural hypotension. Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with β-blockers such as propranolol. The clearance of lidocaine is reduced with administration of propranolol. Lidocaine toxicity has been reported following co-administration with propranolol. Caution should be exercised when administ

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • OFF LABEL USE7,261 reports
  • DRUG INEFFECTIVE5,331 reports
  • NAUSEA4,280 reports
  • HEADACHE3,785 reports
  • FATIGUE3,752 reports
  • DIARRHOEA3,120 reports
  • DIZZINESS3,102 reports
  • PRODUCT USE IN UNAPPROVED INDICATION2,837 reports
  • VOMITING2,653 reports
  • DYSPNOEA2,562 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with propranolol:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.