risperidone

Brand names: RISPERIDONE

# Overview of Risperidone Risperidone is a medication used to treat certain mental health conditions, including schizophrenia, bipolar disorder, and irritability in people with autism. It works by helping to balance chemicals in the brain that affect mood, thoughts, and behavior. Doctors may prescribe it to help reduce symptoms like hallucinations, delusions, or severe mood swings. The medication comes in different forms and strengths, and the dose is adjusted based on each person's needs and how well they respond to treatment. If you take risperidone, it's important to know about possible drug interactions, which happen when this medicine mixes with other medications you're taking. Some medications like carbamazepine can lower the amount of risperidone in your body, which might mean your doctor needs to increase your dose. Other drugs like fluoxetine or paroxetine can increase risperidone levels, so your doctor may need to lower your dose or keep it below 8 mg per day. Always tell your doctor about all medicines, vitamins, and supplements you're taking to make sure risperidone is safe for you. Like all medications, risperidone can cause side effects, so it's important to discuss any concerns with your healthcare provider.

Known Interactions

7 DRUG INTERACTIONS Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone. Increase the risperidone tablets dose up to double the patient’s usual dose. Titrate slowly. ( 7.1 ) Fluoxetine, paroxetine, and other CYP 2D6 enzyme inhibitors increase plasma concentrations of risperidone. Reduce the initial dose. Do not exceed a final dose of 8 mg per day of risperidone tablets. ( 7.1 ) 7.1 Pharmacokinetic-related Interactions The dose of risperidone tablets should be adjusted when used in combination with CYP2D6 enzyme inhibitors (e.g., fluoxetine, and paroxetine) and enzyme inducers (e.g., carbamazepine) [see Table 18 and Dosage and Administration (2.5) ]. Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] . Table 18. Summary of Effect of Coadministered Drugs on Exposure to Active Moiety (Risperidone + 9-Hydroxy-Risperidone) in Healthy Subjects or Patients

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • GYNAECOMASTIA24,608 reports
  • OFF LABEL USE12,325 reports
  • ABNORMAL WEIGHT GAIN9,446 reports
  • WEIGHT INCREASED9,087 reports
  • DRUG INEFFECTIVE7,460 reports
  • EMOTIONAL DISORDER5,947 reports
  • PRODUCT USE IN UNAPPROVED INDICATION5,946 reports
  • INJURY4,625 reports
  • DRUG INTERACTION4,468 reports
  • HYPERPROLACTINAEMIA4,449 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with risperidone:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.