rosuvastatin

Brand names: Rosuvastatin Calcium

# Overview of Rosuvastatin Rosuvastatin is a medication used to help lower cholesterol levels in your body. High cholesterol can build up in your arteries and increase your risk of heart disease and stroke. This medicine works by reducing the amount of cholesterol your liver makes. Your doctor may prescribe rosuvastatin if diet and exercise alone aren't enough to bring your cholesterol to a healthy level. It's usually taken as a pill by mouth once a day. When taking rosuvastatin, it's important to know about some safety rules. If you take antacids (medicines that reduce stomach acid), you should take rosuvastatin at least two hours before taking the antacid. If you take a blood thinner called warfarin, your doctor needs to check your blood clotting levels before you start rosuvastatin and monitor them regularly. Also, rosuvastatin can interact with other medicines, so always tell your doctor about all the medications you're taking. Like all medicines, rosuvastatin can cause side effects, so discuss any concerns with your doctor to make sure it's the right choice for you.

Known Interactions

7 DRUG INTERACTIONS See full prescribing information for details regarding concomitant use of rosuvastatin with other drugs that increase the risk of myopathy and rhabdomyolysis. ( 7.1 ) Aluminum and Magnesium Hydroxide Combination Antacids : Administer rosuvastatin at least 2 hours before the antacid. ( 7.2 ) Warfarin : Obtain INR prior to starting rosuvastatin. Monitor INR frequently until stable upon initiation, dose titration or discontinuation. ( 7.3 ) 7.1 Drug Interactions that Increase the Risk of Myopathy and Rhabdomyolysis with Rosuvastatin Rosuvastatin is a substrate of CYP2C9 and transporters (such as OATP1B1, BCRP). Rosuvastatin plasma levels can be significantly increased with concomitant administration of inhibitors of CYP2C9 and transporters. Table 5 includes a list of drugs that increase the risk of myopathy and rhabdomyolysis when used concomitantly with rosuvastatin and instructions for preventing or managing them [see Warnings and Precautions ( 5.1 ) and Clinical Pha

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • FATIGUE13,910 reports
  • NAUSEA11,738 reports
  • DYSPNOEA11,346 reports
  • DRUG INEFFECTIVE11,329 reports
  • DIARRHOEA10,640 reports
  • PAIN10,407 reports
  • OFF LABEL USE9,868 reports
  • MYALGIA9,727 reports
  • HEADACHE9,515 reports
  • DIZZINESS8,847 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with rosuvastatin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.