semaglutide

Brand names: OZEMPIC, RYBELSUS

# Semaglutide: What You Should Know Semaglutide is a medicine used to help people with type 2 diabetes control their blood sugar levels. It works by helping your body release more insulin when your blood sugar is high, and it also slows down how quickly food moves through your stomach. This helps keep your blood sugar steady throughout the day. The medicine comes as either a pill you swallow or an injection you give yourself once a week, depending on which version your doctor prescribes. Like all medicines, semaglutide can cause side effects and has some important safety points to know. You should tell your doctor about all other medicines you take, especially if you're taking insulin or certain diabetes pills, because semaglutide can work together with these drugs and might cause your blood sugar to drop too low. You should not use this medicine if you have a personal or family history of a certain type of thyroid cancer, and you need to let your doctor know right away if you notice any unusual lumps in your neck, trouble swallowing, or hoarseness. Always follow your doctor's instructions carefully and attend your regular check-ups to make sure this medicine is working safely for you.

Known Interactions

7 DRUG INTERACTIONS Other Oral Drugs : RYBELSUS and OZEMPIC tablets delay gastric emptying. Consider increased clinical or laboratory monitoring when co-administered with other oral medications that have a narrow therapeutic index or that require clinical monitoring. ( 7.2 ) 7.1 Concomitant Use with an Insulin Secretagogue (e.g., Sulfonylurea) or with Insulin Semaglutide stimulates insulin release in the presence of elevated blood glucose concentrations. Patients receiving RYBELSUS or OZEMPIC tablets in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia. When initiating RYBELSUS or OZEMPIC tablets, consider reducing the dosage of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia [see Warnings and Precautions ( 5.4 ), Adverse Reactions ( 6.1 )] . 7.2 Other Oral Drugs Semaglutide cause a delay of gastric emptying and thereby h

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • NAUSEA11,506 reports
  • VOMITING7,479 reports
  • OFF LABEL USE6,855 reports
  • DIARRHOEA6,516 reports
  • DECREASED APPETITE4,790 reports
  • CONSTIPATION4,612 reports
  • WEIGHT DECREASED4,242 reports
  • FATIGUE3,563 reports
  • HEADACHE3,420 reports
  • BLOOD GLUCOSE INCREASED3,066 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with semaglutide:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.