Semaglutide: Uses, Side Effects, and Drug Interactions
Brand names: OZEMPIC, RYBELSUS
# Semaglutide: What You Should Know Semaglutide is a medicine used to help people with type 2 diabetes control their blood sugar levels. It works by helping your body release more insulin when your blood sugar is high, and it also slows down how quickly food moves through your stomach. This helps keep your blood sugar steady throughout the day. The medicine comes as either a pill you swallow or an injection you give yourself once a week, depending on which version your doctor prescribes. Like all medicines, semaglutide can cause side effects and has some important safety points to know. You should tell your doctor about all other medicines you take, especially if you're taking insulin or certain diabetes pills, because semaglutide can work together with these drugs and might cause your blood sugar to drop too low. You should not use this medicine if you have a personal or family history of a certain type of thyroid cancer, and you need to let your doctor know right away if you notice any unusual lumps in your neck, trouble swallowing, or hoarseness. Always follow your doctor's instructions carefully and attend your regular check-ups to make sure this medicine is working safely for you.
Taking Semaglutide with other medications?
Check Semaglutide against any other medication — the form below is already pre-filled.
Check Now ↓Most Reported Side Effects (FAERS)
- NAUSEA11,506 reports
- VOMITING7,479 reports
- OFF LABEL USE6,855 reports
- DIARRHOEA6,516 reports
- DECREASED APPETITE4,790 reports
- CONSTIPATION4,612 reports
- WEIGHT DECREASED4,242 reports
- FATIGUE3,563 reports
- HEADACHE3,420 reports
- BLOOD GLUCOSE INCREASED3,066 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (3)
- Class II
Novo Nordisk Inc. · December 19, 2025
Wegovy (semaglutide) Injection, 0.5 mg/0.5 mL, 4 Single-Dose Prefilled Pens, Manufactured by: Novo Nordisk A/S, DK-2880 Bagsvaerd, Denmark, Product of Denmark, Novo Nordisk A/S, Novo Nordisk Inc., PlaPresence of Particulate Matter: Hair was found in a prefilled syringe
- Class II
Novo Nordisk Inc. · December 19, 2025
Wegovy (semaglutide) Injection, 1 mg/0.5 mL, 4 Single-Dose Prefilled Pens, Manufactured by: Novo Nordisk A/S, DK-2880 Bagsvaerd, Denmark, Product of Denmark, Novo Nordisk A/S, Novo Nordisk Inc., PlainPresence of Particulate Matter: Hair was found in a prefilled syringe
- Class II
Cardinal Health Inc. · April 9, 2025
Wegovy (semaglutide) injection, 2.4 mg/0.75 mL, 4 Single-Dose Prefilled Pens per Carton, For Subcutaneous Use Only, Rx Only, Single-Dose Only, Novo Nordisk Inc., Plainsboro, NJ 08536, Manufactured by:Temperature abuse: Wegovy product was potentially exposed to temperatures outside of the products labeled storage conditions due to a shipping error involving a Cardinal Health distribution center. More specifically, product was removed from refrigerated storage for an extended period of time and inappropriately released.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Check interactions with Semaglutide:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.