sitagliptin

Brand names: ZITUVIMET

# Overview of Sitagliptin Sitagliptin is a medicine used to help people with type 2 diabetes control their blood sugar levels. It works by helping your body release more insulin when your blood sugar gets too high, which helps keep your blood sugar in a healthy range. Doctors prescribe it along with diet and exercise, and it can be used by itself or combined with other diabetes medicines to help manage the condition. While sitagliptin is generally safe for most people, there are some important things to know before taking it. You should tell your doctor about all medicines you take, especially water pills and other drugs that affect your kidneys, since they can increase your risk of serious problems. Common side effects are usually mild and may include headache or sore throat. It's important to take sitagliptin exactly as your doctor tells you and to keep all your doctor's appointments so they can check how well the medicine is working for you.

Known Interactions

7 DRUG INTERACTIONS Table 4 presents clinically significant drug interactions with ZITUVIMET: Table 4: Clinically Significant Drug Interactions with ZITUVIMET Carbonic Anhydrase Inhibitors Clinical Impact: Carbonic anhydrase inhibitors frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis. Concomitant use of these drugs with ZITUVIMET may increase the risk for lactic acidosis. Intervention: Consider more frequent monitoring of these patients. Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide. Drugs that Reduce Metformin Clearance Clinical Impact: Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT 2 ] / multidrug and toxin extrusion [MATE] inhibitors) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology ( 12.3 )]. Intervention: C

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • BLOOD GLUCOSE INCREASED5,855 reports
  • NAUSEA4,780 reports
  • DIARRHOEA4,714 reports
  • DRUG INEFFECTIVE4,364 reports
  • FATIGUE3,695 reports
  • HEADACHE3,048 reports
  • VOMITING3,040 reports
  • DIZZINESS3,019 reports
  • ACUTE KIDNEY INJURY2,931 reports
  • DYSPNOEA2,915 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with sitagliptin:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.