Spironolactone: Uses, Side Effects, and Drug Interactions
Brand names: Spironolactone
# Spironolactone: What You Need to Know Spironolactone is a water pill that helps your body get rid of extra salt and water. Doctors prescribe it mainly to treat high blood pressure and to help your heart work better when it's weakened. It works by blocking a chemical in your body that normally tells your kidneys to hold onto salt and water. By reducing salt and water buildup, the medicine helps lower blood pressure and reduces stress on your heart. It comes in tablet form and your doctor will tell you how much to take based on your condition. Since spironolactone affects how your body handles salt and other minerals, there are some important safety things to know. Never take this medicine with other drugs that increase potassium levels without talking to your doctor first, because too much potassium in your blood can be dangerous. You should also avoid certain common medications like some pain relievers and blood thinners, as they can interfere with how well spironolactone works. Tell your doctor about all medicines you're taking, including over-the-counter drugs, and report any unusual weakness, tiredness, or irregular heartbeat right away. Your doctor may need to check your blood regularly to make sure the medicine is working safely for you.
Taking Spironolactone with other medications?
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Check Now ↓Most Reported Side Effects (FAERS)
- DYSPNOEA10,465 reports
- FATIGUE8,229 reports
- NAUSEA7,868 reports
- DIARRHOEA7,472 reports
- ACUTE KIDNEY INJURY6,792 reports
- DIZZINESS6,274 reports
- HEADACHE5,905 reports
- HYPOTENSION5,841 reports
- OFF LABEL USE5,588 reports
- DRUG INEFFECTIVE5,231 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (1)
- Class II
SUN PHARMACEUTICAL INDUSTRIES INC · August 5, 2025
Spironolactone Tablets, USP, 25 mg, 100-count bottle, Rx only, Mfg. by: Frontida BioPharm, Inc., 1100 Orthodox St, Philadelphia, PA 19124, Dist. by: Sun Pharmaceutical Industries, Inc., Cranbury, NJ 0Presence of foreign substance: identified as aluminum.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Check interactions with Spironolactone:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.