sucralfate

Brand names: Sucralfate

# Sucralfate Overview Sucralfate is a medication used to treat ulcers in the stomach and small intestine. It works by forming a protective coating over the ulcer, which helps it heal and reduces pain. Doctors usually prescribe sucralfate when patients have sores in their digestive tract that need extra protection and care. The medication is taken by mouth and works directly where the ulcer is located, making it a targeted treatment for this specific problem. When taking sucralfate, it's important to know about some safety concerns. This medication can interfere with how your body absorbs other drugs, including antibiotics, heart medications, and thyroid medicine. Because of this, you should take sucralfate at least two hours apart from other medications. Additionally, if you're taking blood thinner medication like warfarin, your doctor will need to monitor you more carefully since sucralfate may affect how well it works. Always tell your doctor and pharmacist about all the medicines you're taking before starting sucralfate to make sure it's safe for you.

Known Interactions

Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. Subtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reports. However, two clinical studies have demonstrated no change in either serum warfarin concentration or prothrombin time with the addition of sucralfate to chronic warfarin therapy. The mechanism of these interactions appears to be nonsystemic in nature, presumably resulting from sucralfate binding to the concomitant agent in the gastrointestinal tract. In all case studies to date (cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine), dosing the concomitant medication 2 hours before sucralfate el

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • NAUSEA2,262 reports
  • FATIGUE1,733 reports
  • DIARRHOEA1,700 reports
  • PAIN1,481 reports
  • HEADACHE1,381 reports
  • VOMITING1,355 reports
  • DYSPNOEA1,302 reports
  • DRUG INEFFECTIVE1,293 reports
  • OFF LABEL USE1,279 reports
  • DIZZINESS1,039 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with sucralfate:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.