tiotropium

Brand names: Stiolto Respimat

# Tiotropium Overview Tiotropium is a medicine used to help people with chronic obstructive pulmonary disease (COPD) and asthma breathe easier. It works by relaxing the muscles around the airways in your lungs, which helps keep them open longer so air can flow more freely. You inhale this medicine using a special inhaler device, usually once a day. It's a maintenance medicine, which means you take it regularly to prevent breathing problems, not just when you're having trouble breathing. While tiotropium is helpful for many people, there are some important safety things to know. Tell your doctor about all other medicines you're taking, especially heart medicines, water pills, certain antidepressants, and other asthma or COPD drugs—some combinations need careful watching. Don't use tiotropium if you're allergic to it or similar medicines. Watch for side effects like tremors, headaches, or heart palpitations, and call your doctor right away if you have chest pain, irregular heartbeat, or severe breathing problems. Always use your inhaler exactly as your doctor instructs and store it properly at room temperature.

Known Interactions

7 DRUG INTERACTIONS Other adrenergic drugs may potentiate effect. Use with caution. ( 5.3 , 7.1 ) Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. Use with caution. ( 7.2 , 7.3 ) MAO inhibitors, tricyclic antidepressants, and drugs that prolong QTc interval may potentiate effect on cardiovascular system. Use with extreme caution. ( 7.4 ) Beta-blockers may decrease effectiveness. Use with caution and only when medically necessary. ( 7.5 ) Anticholinergics: May interact additively with concomitantly used anticholinergic medications. Avoid administration of STIOLTO RESPIMAT with other anticholinergic-containing drugs. ( 7.6 ) 7.1 Adrenergic Drugs If additional adrenergic drugs are to be administered by any route, they should be used with caution because the sympathetic effects of olodaterol, one component of STIOLTO RESPIMAT, may be potentiated [see Warnings and Precautions (5.3 , 5.6 , 5.10 , 5.11) ] . 7.2 Sympathomi

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DYSPNOEA25,050 reports
  • INCORRECT ROUTE OF DRUG ADMINISTRATION23,327 reports
  • ASTHMA12,091 reports
  • DRUG INEFFECTIVE10,352 reports
  • COUGH9,825 reports
  • PNEUMONIA9,260 reports
  • WHEEZING7,488 reports
  • CHRONIC OBSTRUCTIVE PULMONARY DISEASE6,892 reports
  • PRODUCT QUALITY ISSUE6,470 reports
  • FATIGUE5,983 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with tiotropium:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.